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A focused portfolio of non-animal hyaluronic acid fillers by Croma-Pharma, designed for different levels of facial correction, volume enhancement and contour refinement.
For moderate to severe facial wrinkles and folds. The lidocaine formulation is also indicated for lip augmentation. Injected into the mid to deep dermis by a qualified medical professional.
Explore fillerFor deeper facial wrinkles and folds, facial volume enhancement and remodeling of facial contours. The lidocaine formulation contains lidocaine for added comfort during treatment.
Explore volume plusFor the correction of deeper wrinkles and folds and for building facial volume or remodeling facial contours. The lidocaine formulation contains lidocaine for added comfort during treatment.
Explore volume
Founded in Austria in 1976, Croma-Pharma is a family-owned company focused on the industrial production of hyaluronic acid syringes for medical aesthetics, ophthalmology and orthopaedics. Croma has developed hyaluronic-acid cross-linking expertise since 2002, manufactures at its headquarters in Leobendorf near Vienna, and distributes its products in more than 70 countries through 12 international sales companies. Saypha® reflects this focus on medical science, quality and reliable professional use.
BDDE is one of the most widely used cross-linking agents in HA dermal fillers. Understanding its role, the cross-linking reaction and control of residual BDDE is an important part of understanding filler manufacturing and quality.
The physical structure of an HA filler can influence its rheological behavior, injectability and interaction with tissue. Particle or gel-structure characteristics are therefore relevant considerations in filler formulation and manufacturing.
The quality of an HA dermal filler depends on multiple factors extending from the starting HA material to cross-linking, purification, formulation, filling and final quality control.
Saypha® is Croma-Pharma’s brand of hyaluronic acid dermal fillers. The range includes products for skin hydration, wrinkle correction, lip augmentation, facial volume enhancement and contour remodeling, depending on the individual product and its approved indication.
Saypha® filler is intended for moderate to severe facial wrinkles and folds, with lip augmentation indicated for the lidocaine formulation. Saypha® volume is intended for deeper wrinkles, facial volume enhancement and contour remodeling. Saypha® volume plus Lidocaine is intended for facial tissue augmentation, midface volume deficit and facial contouring. Product selection must follow the official instructions for use.
Saypha® products are for professional use only. Injection depth, product selection and technique must be determined and performed by a qualified medical professional in accordance with the official instructions for use and applicable local regulations.
